institute of primate translational medicine, kunming university of science and technology, yunnan zhongke primate biomedical key laboratory

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institute of primate translational medicine, kunming university of science and technology, yunnan zhongke primate biomedical key laboratory / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = s h o r t c u t i c o n t y p e = i m a g e / x i c o n > / q u a l i t y / 9 0 ! / f o r m a t / p n g p r o p e r t y = o g : i m a g e > / q u a l i t y / 9 0 ! / f o r m a t / p n g i t e m p r o p = i m a g e > / q u a l i t y / 9 0 ! / f o r m a t / p n g n a m e = t w i t t e r : i m a g e > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 5 8 x 5 8 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 7 6 x 7 6 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 8 0 x 8 0 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 8 7 x 8 7 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 1 1 4 x 1 1 4 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 1 2 0 x 1 2 0 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 1 5 2 x 1 5 2 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 1 6 7 x 1 6 7 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g r e l = a p p l e t o u c h i c o n s i z e s = 1 8 0 x 1 8 0 / > / q u a l i t y / 9 0 ! / f o r m a t / p n g w i d t h = 3 0 0 h e i g h t = 3 0 0 a l t = t h u m b n a i l i m a g e / > / q u a l i t y / 9 0 ! / f o r m a t / p n g a l t = b r o k e n i m a g e t i t l e = c l a s s = c r o p d e f a u l t d a t a d e s c r i p t i o n = d a t a i m a g e l i n k = j a v a s c r i p t : v o i d ( 0 ) ; / > / q u a l i t y / 9 0 ! / f o r m a t / p n g a l t = b r o k e n i m a g e t i t l e = c l a s s = c r o p d e f a u l t d a t a d e s c r i p t i o n = d a t a i m a g e l i n k = j a v a s c r i p t : v o i d ( 0 ) ; / > home news research field primate reproduction, development and disease primate stem cells and tissue organ regeneration human complex disease animal models and biotherapy support platform scientific research achievements talent team open exchange paper join us recruitment information common documents for admissions information / q u a l i t y / 9 0 ! / f o r m a t / p n g ) d a t a b g = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F j d k C s p k u 7 G h 4 v 8 P k p I A w 5 S 4 Z 2 f C . p n g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 2 0 0 0 x 1 5 0 0 > / q u a l i t y / 9 0 ! / f o r m a t / p n g d a t a r e a c t s t y l e = > / q u a l i t y / 9 0 ! / f o r m a t / p n g ) d a t a b g = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F o c n b 9 C a w K J k _ J h q F 4 n l e D G A q Y e . p n g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 2 0 0 0 x 1 5 0 0 > / q u a l i t y / 9 0 ! / f o r m a t / p n g d a t a r e a c t s t y l e = >   / q u a l i t y / 9 0 ! / i n t e r l a c e / 1 / f o r m a t / j p e g ) d a t a b g = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F m S e O 5 j X y D 6 7 9 y s q w 8 6 f l R C n d q V o . j p g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 2 0 0 0 x 1 5 0 0 > / q u a l i t y / 9 0 ! / i n t e r l a c e / 1 / f o r m a t / j p e g d a t a r e a c t s t y l e = > news first round meeting notice | “ 10th international symposium on primate biomedical science 2 02 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 2 0 2 5 the measures for the selection of graduate scholarships of the institute of primate translational medicine on 2024-11-2024-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-2012-201 [ 2 0 1 9 ] 6 4 no.) (see the 2020 edition of the "kunming university of science and technology graduate manual" for details) related topics. . . news | “ academician ji weizhi was selected C e l l P r e s s “ 5 0 S c i e n t i s t s t h a t I n s p i r e ” and interviewed on january 25, 2024 C e l l publishing house published the first issue in 1974 C e l l it has been 50 years since the magazine. as one of the top international journals, C e l l with the purpose of "exciting biological research", the publication fields include but are not limited to cell biology, molecular biology, neuroscience, immunology, . . view more scientific research results / q u a l i t y / 9 0 ! / f o r m a t / p n g d a t a s r c = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F v C V m u v z M Z b a e H R v b 3 7 R G P i x X I K 1 . p n g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 1 2 0 0 x 9 0 0 0 > / q u a l i t y / 9 0 ! / f o r m a t / p n g / > establishment of three early embryo stem cell lines in the same culture conditions to analyze the cell interaction relationship and mechanism during early development. on january 4, 2023, the province and the ministry jointly established the national key laboratory of non-human primate biomedical / tan tao, institute of primate translational medicine, kunming university of science and technology / ji weizhi's team, wu jun, southwest medical center, texas, usa / wei yulei, china agricultural university / yu leqian, institute of zoology, chinese academy of sciences, cooperated in C E L L the magazine published the title " D i s s e c t i n g e m b r y o n i c a n d e x t r a e m b r y o n i c l i n e a g e c r o s s t a l k w i t h s t e m c e l l c o c u l t u r e ” articles.   the study found that the blastocysts from mice and cynomolgus monkeys can be established under the same culture system E S C s 、 X E N s and T S C s cell lines construct the cell interaction environment during blastocyst period through stem cell co-culture, and elucidate the interaction and regulatory mechanism between embryonic tissue and extraembryonic tissue during blastocyst period. this study not only provides a new paradigm for the analysis of the interaction mechanism between embryos and extraembryonic tissues, but also helps us to deeply understand the complex regulatory patterns of early embryonic development.   original: h t t p s : / / w w w . s c i e n c e d i r e c t . c o m / s c i e n c e / a r t i c l e / a b s / p i i / S 0 0 9 2 8 6 7 4 2 3 0 1 2 2 5 4 / q u a l i t y / 9 0 ! / f o r m a t / p n g d a t a s r c = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F k P 2 U N g e k l T w f z P p L b B e E H 8 G F X 7 4 . p n g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 1 2 0 0 x 9 0 0 0 > / q u a l i t y / 9 0 ! / f o r m a t / p n g / > developing a long-term culture system for cynomolgus monkeys reveals the regulation mechanism of early primate organisms 2 0 2 3 may 1 2 3, the province and the ministry jointly established the national key laboratory of non-human primate biomedical / tan tao, institute of primate translational medicine, kunming university of science and technology / chen yongchang / ji weizhi's team, general hospital of the people's liberation army of china / liu bing's team in the national key laboratory of blood and health and wu jun's team in dezhou southwest medical center cooperated with C e l l the journal publishes the latest research results E x u t e r o m o n k e y e m b r y o g e n e s i s f r o m b l a s t o c y s t t o e a r l y o r g a n o g e n e s i s ” 。   this study developed a kind of cynomolgus monkey embryos that can support in vitro development to early organogenesis 3 D the culture system and systematically study the important cellular composition and lineage differentiation trajectory of non-human primates from gastrulation to early organogenesis. the research results will help understand the early miscarriage of human embryo development malformations.   original: h t t p s : / / w w w . c e l l . c o m / c e l l / f u l l t e x t / S 0 0 9 2 8 6 7 4 ( 2 3 ) 0 0 4 1 6 6 / q u a l i t y / 9 0 ! / f o r m a t / p n g d a t a s r c = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F l F 1 s u 5 5 K 2 G f Q 8 K l t H L 3 y F F l y Z M I . p n g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 1 2 0 0 x 9 0 0 0 > / q u a l i t y / 9 0 ! / f o r m a t / p n g / > revealing the chimeric ability of heterogeneous cells2 021-15, the province and the ministry jointly established the national key laboratory of non-human primate biomedical / academician ji weizhi's team, tan tao, niu yuyu, dai shaoxing's research team and the united states S a l k the institute cooperates in C e l l the latest research results were published in the journal C h i m e r i c c o n t r i b u t i o n o f h u m a n e x t e n d e d p l u r i p o t e n t s t e m c e l l s t o m o n k e y e m b r y o s e x v i v o ” 。   tan tao and other researchers combined with the previously established in vitro culture system of monkey embryos to evaluate human extended pluripotent stem cells ( h E P S ） ( Y a n g e t a l . , 2 0 1 7 ) chimeric ability in cynomolgus monkeys. revealed h E P S it can be chimeric into the cynomolgus monkey embryo, and can enter the gastrulation movement along with the embryo development, expressing the mesoderm and endoderm. m a r k e r gene; h E P S cells are difficult to differentiate into trophoblast cells in cynomolgus monkey embryos, but are more likely to differentiate into epidermal ( e p i b l a s t ， E P I ） cells, this discovery is h E P S there are certain differences in the experiments of human-mouse chimera in cell. by further binding to single cells R N A sequencing and other technologies, researchers found h E P S as the development progresses, the expression characteristics gradually become similar to the receptor cynomolgus monkey embryo cells, and vice versa. through cell interaction analysis, humans and monkeys are revealed in the following areas E P I specific interactions between cells, e.g. F G F 5 F G F R 4 ， at the same time, the cell interaction between the receptor monkey embryonic cells itself has also been enhanced, mainly involving P I 3 K A k t and M A P K family of signals; h E P S the developmental progress in chimeric embryos is significantly slower than that of normal-developed humans and cynomolgus monkey embryos. it is also possible with P I 3 K A k t and M A P K changes in signal pathways are closely related. this study answers basic scientific questions such as how xenochimeric cells interact and how to regulate developmental program differences, providing new ideas for solving problems such as inefficient xenochimeric, and is of guiding significance for organ regeneration research.   original: h t t p s : / / w w w . c e l l . c o m / c e l l / f u l l t e x t / S 0 0 9 2 8 6 7 4 ( 2 1 ) 0 0 3 0 5 6 ? u t m _ s o u r c e = E A / q u a l i t y / 9 0 ! / f o r m a t / p n g d a t a s r c = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F s z p M l T V Z G i X 3 z Y E Q W e z y s u 2 P Z L . p n g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 1 2 0 0 x 9 0 0 0 > / q u a l i t y / 9 0 ! / f o r m a t / p n g / > drawing a panoramic map of the development of pre-gastric embryos of human gastrulation 2 0 1 2 0 1 9, institute of primate transformation, kunming university of science and technology / li tianqing and ji weizhi's team of yunnan zhongke primate biomedical key laboratory cooperated with the department of reproductive department of yunnan first people's hospital to announce the development of a three-dimensional (3 D ） the human blastocyst culture system was used, and the developmental panoramic view of the pre-gastric embryos of human gastrulation was drawn for the first time, which established an important research foundation for studying the early embryo development after human implantation. the relevant research results were titled " A d e v e l o p m e n t a l l a n d s c a p e o f 3 D c u l t u r e d h u m a n p r e g a s t r u l a t i o n e m b r y o s ” in the top international magazine "nature" ( N a t u r e ） this study systematically studied the development process of gastrula prenatal embryos and pluripotent stem cells for the first time, and drew a panoramic view of the molecular and morphological development of gastrula prenatal embryos, filling the gaps in related fields. the establishment of a three-dimensional human embryo culture system has opened up a new research platform for exploring the development of pre-human gastrulation, providing potential new tools for the development of clinical drugs for major diseases such as abnormal embryos in early human embryo development and the development of regenerative medicine. in the future, this technology will combine human stem cell self-assembly and other technologies to embryos, and will further analyze the embryo differentiation process and related signal pathway regulation, providing important data for humans to deeply understand the embryo development mechanism.   original: h t t p s : / / w w w . n a t u r e . c o m / a r t i c l e s / s 4 1 5 8 6 0 1 9 1 8 7 5 y / i n t e r l a c e / 1 / f o r m a t / j p e g d a t a s r c = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F v L z E D q c D p i I I f 0 K y V v O N 2 K e Z D u . j p g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 1 2 0 0 x 9 0 0 0 > / i n t e r l a c e / 1 / f o r m a t / j p e g / > revealing the early embryo development map of primate cultured in vitro 2 0 10-3 1, 19, institute of primate translational medicine, kunming university of science and technology / teams of professors tan tao, niu yuyu and academician ji weizhi from the key laboratory of primate biomedical sciences in yunnan zhongke and salk, usa ( S a l k ) research institute, shenzhen huada life science research institute and other units cooperated in the journal science ( S c i e n c e ） publish research results online” D i s s e c t i n g p r i m a t e e a r l y p o s t i m p l a n t a t i o n d e v e l o p m e n t u s i n g l o n g t e r m i n v i t r o e m b r y o c u l t u r e ” 。   the research team achieved 20 days of in vitro culture of cynomolgus monkey embryos, and the cultured embryos showed morphological and gene expression characteristics that were highly consistent with the developing embryos in vivo. combined with the embryo in vitro culture system and single-cell multi-omic sequencing technology, the research team sequenced the in vitro cultured embryos 9 days after fertilization. through cell lineage and molecular trajectory changes, the researchers systematically studied epidermal cells. ( e p i b l a s t ) the dynamic process of pluripotency changes reveals the oxidative phosphorylation pathway in n a ï v e role in pluripotency maintenance; single-cell transcriptome data of trophoblast lineages show differentiation pathways in trophoblast lineages and indicate well-recognized trophoblast stem cells in mice m a r k e r C D X 2 expression cannot be maintained in early embryonic development of primates, which put forward new insights on the development of primate trophoblasts; the research results also reveal the interactions between different cell lineages in embryonic development after primate implantation, in order to further understand the microenvironment of embryonic development after implantation. ( n i c h e ) the important role of the company provides new ideas. more importantly, the research results reveal that the amniotic epithelium is the potential origin of primitive germ cells, but it is not ruled out e p i b l a s t source. although further in-depth and meticulous mechanism research is needed to confirm, the current research results are for primates P G C the early origins of the stakes provide new insights. this research work uses an in vitro system for the first time to analyze important molecular and cellular biological events after primate embryo implantation, especially during gastrulation. the research results help deepen people's understanding of embryonic development after early implantation, and are also guiding for cell replacement therapy and organ regeneration research.   original: h t t p s : / / s c i e n c e . s c i e n c e m a g . o r g / c o n t e n t / e a r l y / 2 0 1 9 / 1 0 / 3 0 / s c i e n c e . a a w 5 7 5 4 / i n t e r l a c e / 1 / f o r m a t / j p e g d a t a s r c = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F k p w J Z p V F Y M m V d B 7 z g G W E 5 E e G L I O . j p g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 1 2 0 0 x 9 0 0 0 > / i n t e r l a c e / 1 / f o r m a t / j p e g / > targeted gene editing technology to establish monkey model of rett syndrome 2017, the top international journal " C e l l 》 published by kunming university of science and technology, yunnan province primate biomedical key laboratory, chen yongchang's team and sun yi's team of the school of medicine of tongji university, and T A L E N technological development of cynomolgus monkey ret syndrome ( R e t t s y n d r o m e ， R T T ） model research. R T T it is a neurodevelopmental disease belonging to the autism spectrum, which usually causes male fetus to have miscarriage during the embryonic stage. the sick girl begins to show syndromes such as loss of language ability, poor sleep quality, social and cognitive impairment, slowing brain development, abnormal electrocardiogram, and abnormal motor ability at 618 months after birth. location X on chromosomes M E C P 2 gene mutations are the cause of this disease. the lack of ideal animal models is for them yet to be cured R T T method. there are great differences between previous mouse models and clinical patients, and it is difficult to use these models to promote in-depth understanding of the key reasons for the research on pathogenic mechanisms and the development of new treatment methods. because non-human primates (such as macaques and cynomolgus monkeys) have a highly similar genetic background and brain structure to humans, they are the most ideal experimental animals for brain development and neurological diseases. to build R T T monkey model, researchers from kunming university of science and technology, yunnan primate biomedical key laboratory and tongji university school of medicine, first reported the use of targeted gene editing methods in early 2014 after more than a year of research. T A L E N successfully edited M E C P 2 progress in research on monkey model of genes, related results are published in C e l l s t e m c e l l 》 in magazine, this is the first time in the world to successfully edit primates M E C P 2 gene. this time in C e l l 》 reports: different from rodent models, gene mutations M E C P 2 the little monkeys showed a series of pathological and behavioral characteristics that were very similar to clinical patients. for example, male fetus miscarriage during the embryonic stage. transcriptome analysis found that gene expression and regulatory networks were similar to clinical patients. female animals had sleep disorders, significantly reduced active social interaction, increased stereotyped behavior, abnormal brain development, etc.; eye movement tracking (higher cognitive abilities that primates have) patterns are also similar to humans. this is the first time that non-human primate pairs are used R T T from a more systematic study of behavioral patterns, pathological occurrence and its mechanisms, it not only proves that non-human primates have unmatched advantages in neurological diseases than rodents, but also conducts more in-depth development in the future R T T pathogenesis research and treatment will have profound impacts.   original: h t t p : / / w w w . c e l l . c o m / c e l l / f u l l t e x t / S 0 0 9 2 8 6 7 4 ( 1 7 ) 3 0 4 8 9 0 / q u a l i t y / 9 0 ! / i n t e r l a c e / 1 / f o r m a t / j p g d a t a s r c = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F s 8 B C b t z R n x o L R t 6 V 4 3 b o A q X s G j 1 . j p g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 1 2 0 0 x 9 0 0 0 > / q u a l i t y / 9 0 ! / i n t e r l a c e / 1 / f o r m a t / j p g / > primate embryonic stem cells with chimeric ability on june 3, 2014, by improving the culture conditions of stem cells, the key laboratories isolated and established cynomolgus monkey embryonic stem cells that can produce chimeric monkeys for the first time. these stem cells have the growth characteristics and cell morphology of mouse stem cells. when these n a i v e stem cells are injected into early muru embryos of monkeys through microinjection. they can be integrated and chimeric into monkey embryos and differentiated into various tissue cells and germ cells in the body. the results of the study were published in C e l l S t e m C e l l 》 （ C e l l s t e m c e l l . 2 0 1 4 ; 1 4 ( 3 ) : 3 2 3 3 2 8 ） 。 establishing all-purpose stem cells and producing chimeric animals has great scientific and applied value: 1) to establish primates (including humans) P S C s identification standards and understanding N a i v e characteristics provide a research material and technology platform; through monkey N a i v e P S C s and no chimeric ability P r i m e d P S C s comparative analysis of differences in gene expression profile, epigenetics and histones can screen out primates P S C s molecular markers, establishing primates including humans P S C s , the pluripotency identification standards and evaluation system of the pluripotency identification standards and evaluation systems promote the standardized production of stem cells and the directed differentiation of functional cells, and promote the entry of stem cells into the clinical trials; 2) it can realize the regeneration of tissues and organs in the body, providing an important research basis for the final regeneration of functional organs in the body for patient organ transplantation; 3) combined with gene-directed modification technology, it is necessary to establish a non-human primate model with a complete genetic background for specific human diseases.   original: h t t p : / / w w w . c e l l . c o m / c e l l s t e m c e l l / a b s t r a c t / S 1 9 3 4 5 9 0 9 ( 1 5 ) 0 0 2 6 4 7 ​ / q u a l i t y / 9 0 ! / i n t e r l a c e / 1 / f o r m a t / j p g d a t a s r c = / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F s 0 0 e o z c H F y d J 4 1 A 2 q w B 0 4 V j x w c . j p g ? i m a g e M o g r 2 / s t r i p / a u t o o r i e n t / t h u m b n a i l / 1 2 0 0 x 9 0 0 0 > / q u a l i t y / 9 0 ! / i n t e r l a c e / 1 / f o r m a t / j p g / > the world's first targeted gene-edited primate 2014 february 13, 2014, the key laboratories cooperated with domestic research groups to use C R I S P R / C a s 9 system, select 3 target genes N r 0 b 1 、 P p a r c、R a g 1 ， will C a s 9 m R N A and 3 gene-specific s g R N A the mixture was injected into the first-cell stage embryo of the cynomolgus monkey. 2 genes were successfully achieved ( P p a r c and R a g 1 ） the double knockout was successfully obtained for the first time C a s 9 mediated knockout of cynomolgus monkeys. the research results are based on the first unit in C e l l 》 posted on ( C e l l . 2 0 1 4 ; 1 5 6 ( 4 ) : 8 3 6 8 4 3 ） ， it has attracted widespread attention. more than a dozen foreign media reported it. N a t u r e the magazine calls this result " M i l e s t o n e f o r t a r g e t e d g e n e e d i t i n g t e c h n o l o g y p r o m i s e s b e t t e r m o d e l s f o r h u m a n d i s e a s e s ” 。 2 0 1 4 at the end of the year, the study was N a t u r e selected as one of the successful research events in 2014 years ( h t t p : / / w w w . n a t u r e . c o m / n e w s / 3 6 5 d a y s 2 0 1 4 i n s c i e n c e 1 . 1 6 5 7 3 ） 。 this article was rated 2 0 1 4 years C e l l one of the 10 best research papers ( h t t p : / / o n l i n e d i g e d i t i o n s . c o m / p u b l i c a t i o n / f r a m e . p h p ? i = 2 3 6 8 0 1 2 5 ( 2 ) : 2 6 2 2 6 5 ） 。   original: h t t p : / / w w w . c e l l . c o m / c e l l / f u l l t e x t / S 0 0 9 2 8 6 7 4 % 2 8 1 4 % 2 9 0 0 0 7 9 8 contact us name email message submit C o m m e n t institute of primate translational medicine, kunming university of science and technology, chenggong district, kunming city, yunnan province 0 8 7 1 6 5 9 4 6 6 2 5 0 8 7 1 6 5 9 4 6 6 2 5 i n f o @ l p b r . c n related links ministry of science and technology of kunming university of science and technology l l national natural science foundation of china l l chinese society of cell biology l l the chinese physiological society shall not use portraits, pictures and texts of this website without permission. © C o p y r i g h t institute of primate translational medicine, kunming university of science and technology, yunnan zhongke primate biomedical key laboratory I C P preparation no. 1 9 0 0 3 5 5 1 yunnan I C P preparation 1 2 0 0 1 3 0 8 no. 1 institute of primate translational medicine, kunming university of science and technology, yunnan zhongke primate biomedical key laboratory W e b s i t e h t t p : / / u s e r a s s e t s . s x l c d n . c o m / i m a g e s / 9 3 6 5 5 / F g c a 4 0 a K 4 J 8 Q r o E K z 3 i 5 T L o N T e . p n g ? i m a g e M o g r 2 / s t r i p / t h u m b n a i l / 1 2 0 0 x 6 3 0 > / q u a l i t y / 9 0 ! / f o r m a t / p n g C o o k i e we use c o o k i e s to ensure a smooth browsing experience. if it continues, we think you accept the use c o o k i e s 。 confirm to learn more

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